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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC7
All Species:
18.18
Human Site:
T436
Identified Species:
50
UniProt:
O00311
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00311
NP_001127891.1
574
63888
T436
T
I
R
G
S
R
E
T
I
Q
A
A
K
T
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097186
574
63766
T436
T
I
R
G
S
R
E
T
I
Q
A
A
K
T
F
Dog
Lupus familis
XP_537080
756
83548
T618
T
I
R
G
S
R
E
T
I
Q
A
A
K
T
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0H0
564
62734
T427
T
I
R
G
S
R
E
T
I
Q
A
A
K
A
F
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521163
410
45484
A278
Q
S
K
T
M
D
L
A
S
R
K
M
T
K
K
Chicken
Gallus gallus
XP_422347
564
62394
T432
T
V
R
G
S
R
E
T
I
Q
A
A
K
T
F
Frog
Xenopus laevis
NP_001081878
483
53563
Q351
R
G
S
K
E
T
I
Q
A
S
K
C
F
G
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785538
591
65818
Q457
D
D
F
T
A
L
A
Q
I
M
S
I
M
G
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06243
507
58302
Y374
N
G
L
K
E
F
V
Y
D
L
L
N
K
E
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.8
68.9
N.A.
78
N.A.
N.A.
61.3
67.2
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
Protein Similarity:
100
N.A.
97.7
71.5
N.A.
84.8
N.A.
N.A.
65.6
78.7
66.9
N.A.
N.A.
N.A.
N.A.
N.A.
54.4
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
N.A.
N.A.
0
93.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
N.A.
N.A.
13.3
100
0
N.A.
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
12
12
12
0
56
56
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
12
% C
% Asp:
12
12
0
0
0
12
0
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
23
0
56
0
0
0
0
0
0
12
0
% E
% Phe:
0
0
12
0
0
12
0
0
0
0
0
0
12
0
56
% F
% Gly:
0
23
0
56
0
0
0
0
0
0
0
0
0
23
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
45
0
0
0
0
12
0
67
0
0
12
0
0
0
% I
% Lys:
0
0
12
23
0
0
0
0
0
0
23
0
67
12
23
% K
% Leu:
0
0
12
0
0
12
12
0
0
12
12
0
0
0
0
% L
% Met:
0
0
0
0
12
0
0
0
0
12
0
12
12
0
0
% M
% Asn:
12
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
0
0
0
0
0
0
23
0
56
0
0
0
0
0
% Q
% Arg:
12
0
56
0
0
56
0
0
0
12
0
0
0
0
0
% R
% Ser:
0
12
12
0
56
0
0
0
12
12
12
0
0
0
0
% S
% Thr:
56
0
0
23
0
12
0
56
0
0
0
0
12
45
12
% T
% Val:
0
12
0
0
0
0
12
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _